Here is the list of 88 drugs marketed in France that are considered “dangerous”

The specialized journal “Prescrire” published on Wednesday, December 7, its 2023 report on substances to be excluded. A total of 107 substances appear on this list, of which 88 are marketed in France.

Prescrire magazine published the list of drugs to be banned “for better care” on Wednesday, December 7. 107 medicinal products have thus been allocated, of which 88 are marketed in France.


The list of drugs that Prescrire advises to discard from treatment and replace with better options evolves every year, taking into account advances in knowledge.

To read further ➡

— Prescribe (@RevuePrescrire) 29 November 2022

All have a marketing authorization, French or European, and “Prescrire” has subjected them to a rigorous evaluation based on documentary research, relevant efficacy criteria for patients and consideration of side effects.

Drugs that are more dangerous than helpful

The 107 drugs reported by the specialized journal thus represent “an unfavorable balance between benefits and risks in all the clinical situations in which they are approved”.

Specifically, these substances are considered to be more dangerous than useful. Sometimes it can just be a certain form or dose. The specialized journal, whose articles are for the most part written by health professionals, explains on a case-by-case basis the reason for the unfavorable benefit-risk balances. Alternatives that are more beneficial to patients are offered where possible.

The 88 drugs marketed in France “must be excluded”

Drugs used in hematology and for transplants
Defibrotide (Defitelio)

Antitumor medication
Panobinostat (Farydak)
Trabectedin (Yondelis or other)
Vandetanib (Caprelsa)
Vinflunine (Javlor)

Medicines prescribed in cardiology
Bezafibrate (Befizal)
Ciprofibrate (Lipanor or other)
Fenofibrate (Lipanthyl or other)
Dronedarone (Multaq)
Ivabradine (Procoralan or other)
Nicorandil (Ikorel or other)
Olmesartan (Alteis, Olmetec, Alteisduo, Coolmetec, Axeler, Sevikar)
Trimetazidine (Vastarel or other)

Medicines used in dermatology and against allergies
Finasteride 1mg (Propecia or other)

Mequitazine (Primalan)
Dermal tacrolimus (Protopic or other)
Promethazine injection (Phenergan)

Diabetes medication
Gliptins: alogliptin (Vipidia, Vipdomet), linagliptin (Trajenta, Jentadueto), saxagliptin (Onglyza, Komboglyze), sitagliptin (Januvia, Xelevia, Janumet, Velmetia) and vildagliptin (Galvus, Eucreas)

Medicines used for weight loss
Orlistat (Xenical or other)

Certain non-steroidal anti-inflammatory drugs
Aceclofenac (Cartrex or other)
Oral diclofenac (Voltaren or other)
Coxibs: celecoxib (Celebrex or other), etoricoxib (Arcoxia or other), and parecoxib (Dynastat)
Ketoprofen gel (Ketum gel or other)
Meloxicam (Mobic or other)
Piroxicam (Feldene or other)
Systemic tenoxicam (Tilcotil)

Medicine for osteoarthritis
Diacerein (Art 50 or other)
Glucosamine (Flexea or other)

Muscle relaxants
Methocarbamol (Lumirelax)
Thiocolchicoside (Miorel or other)

Medicines for osteoporosis
Denosumab 60 mg (Prolia)

Drugs used in rheumatology
Capsaicin patches (Qutenza)
The combination of colchicine, opium powder and thiemonium (Colchimax)
Quinine (Hexaquine, Okimus)

Drugs used in gastroenterology

Obeticholic acid (Ocaliva)
Medicinal clays: diosmectite (Smecta or other), hydrotalcite (Rennieliquo), beidellitic montmorillonite or monmectite (Beldelix, Gelox) and kaolin (Gastropax, Neutroses)
Domperidone (Motilium or other)
Droperidol (droleptan or other)
Metopimazine (Vogalene, Vogalib)
Prucalopride (Resolor)
Tincture of opium (Dropizal)
Glyceryl trinitrate, 0.4% ointment (rectogesic)

Drugs used in gynecology and endocrinology
Tibolone (livial or other)

Medicines against infections
Moxifloxacin (Izilox or other)

Drugs for Alzheimer’s disease
Donepezil (Aricept or other)
Galantamine (Reminyl or other)
Rivastigmine (Exelon or other)
Memantine (Ebixa or other)

Medication for multiple sclerosis
Natalizumab (Tysabri)

Other drugs used in neurology
Fenfluramine (Fintepla)
Flunarizine (Sibelium)
Oxetorone (Nocertone)
Ginkgo biloba (Tanakan or other)
Naftidrofuryl (Naftilux or other)
Piracetam (Nootropyl or other)
Tolcapone (Tasmar)

cough medicine
Ambroxol (Muxol or other)
Bromhexine (Bisolvon)
Oxomemazine (Toplexil or other)
Pentoxyverine (Pentoxyverine Clarix 0.15%)

Medicine for sore throat
Alpha-amylase (Maxilase or other)
Tixocortol Oral Spray (Rhinadvil sore throat)
Medicines used in pneumology and ENT
Oral and/or nasal decongestants: ephedrine, naphazoline, oxymetazoline, phenylephrine, pseudoephredine, tuaminoheptane
Nintedanib (Ofev)

Medication for depression
Agomelatine (Valdoxan or other)
Citalopram (Seropram)
Escitalopram (Seroplex or other)
Duloxetine (Cymbalta or other)
Milnacipran (Milnacipran Arrow or other)
Venlafaxine (Effexor LP or other)
Esketamine nasal spray solution (Spravato)
Tianeptine (Stablon or other)

Other psychotropic agents
Dapoxetine (Priligy)
Etifoxine (Stresam)

Medicines for smoking cessation
Buproprion (Zyban)

Drugs used in urology
Oral pentosan polysulfate (Elmiron)

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